Thermo Fisher Scientific COCH Polyclonal Antibody
COCH 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, Flow cytometry에 사용 가능. Human 반응성 검증 완료. KLH 결합 합성 펩타이드(aa 399-428)를 면역원으로 제작. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
- 카탈로그번호
- PA548475
- 판매단위
- pk
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Thermo Fisher Scientific COCH Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 399–428 amino acids from the central region of human COCH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2633932 |
Product Specific Information
Predicted to react with bovine based on sequence homology.
Target Information
Cochlin is a secreted protein encoded by the coagulation factor C homology (COCH) gene, a cochlear gene. It constitutes approximately 70% of the inner ear proteins and exists as three glycosylated isoforms: p63s, p44s, and p40.
Cochlin contains an N-terminal LCCL domain and two von Willebrand factor A-like domains.
Mutations in the COCH gene cause DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder, due to amino acid deletions or missense substitutions in the LCCL domain.
Microfibrillar deposits accumulate in the inner ear of individuals with DFNA9, potentially containing Cochlin protein.
Cochlin is a target antigen for autoimmune sensorineural hearing loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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