Thermo Fisher Scientific Human IDH1 Synthetic Peptide
인간 IDH1 단백질의 C-말단 13개 아미노산 서열 기반 합성 펩타이드. 항체 PA5-20976의 블로킹 펩타이드로 사용 가능. PBS(pH 7.2)와 0.1% BSA 용액 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human IDH1.
PEP-1090 can be used as a blocking peptide with polyclonal antibody PA5-20976.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported:
- Three NAD(+)-dependent isocitrate dehydrogenases (mitochondrial matrix localization)
- Two NADP(+)-dependent isocitrate dehydrogenases (one mitochondrial, one cytosolic)
The NADP(+)-dependent cytoplasmic enzyme encoded by this gene is found in the cytoplasm and peroxisomes and contains a PTS-1 peroxisomal targeting signal sequence. Its presence in peroxisomes suggests roles in:
- Regeneration of NADPH for intraperoxisomal reductions (e.g., conversion of 2,4-dienoyl-CoAs to 3-enoyl-CoAs)
- Peroxisomal reactions consuming 2-oxoglutarate (e.g., α-hydroxylation of phytanic acid)
The cytoplasmic enzyme plays a significant role in cytoplasmic NADPH production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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