Thermo Fisher Scientific MUC1 Monoclonal Antibody (OTI1F3), TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:100–1:1,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with each allele encoding a product containing a different number of repeats (30–90), leading to large differences in molecular weight.
It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is abundantly expressed in >90% of breast carcinomas and metastases.
Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
The MUC1 gene contains seven exons and produces several alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of MUC1 protein have been associated with carcinomas.
Multiple alternatively spliced transcript variants encode different isoforms of MUC1, but the full-length nature of only some has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.