Thermo Fisher Scientific MTBP Monoclonal Antibody (PHL-1)
MTBP 단백질을 인식하는 PHL-1 클론의 Mouse Monoclonal Antibody로, 인간 및 침팬지 반응성이 검증됨. Western blot과 ELISA에 사용 가능. MDM2-p53 경로 연구에 적합하며, -20°C 보관으로 안정성 유지.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:2,000
ELISA
- Tested Dilution: 1:2,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chimpanzee, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PHL-1 |
| Immunogen | Recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues 667–812 of human MTBP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | 0.02M potassium phosphate/ascites, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is directed against human MTBP protein. The product was produced from clarified mouse ascitic fluid.
A BLAST analysis suggests reactivity with human (100% homology) and chimpanzee MTBP protein.
Cross-reactivity with mouse (77%) and chicken (79%) MTBP proteins is unlikely due to low positive residues and high sequence gaps.
Cross-reactivity with MTBP homologues from other species has not been determined.
Target Information
MTBP inhibits cell migration in vitro and suppresses tumor cell invasiveness.
It may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells by inhibiting MDM2 autoubiquitination, enhancing its stability, and promoting TP53/p53 degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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