Thermo Fisher Scientific SLC8A2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SLC8A2 for IHC applications. Recognizes sodium/calcium exchanger proteins with high species homology. Supplied as unconjugated liquid form, purified by antigen affinity chromatography, ideal for brain and card...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC8A2. Recombinant protein control fragment (Product #RP-98989). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647566 |
Product Specific Information
- Immunogen sequence: AGEDEDDGAS RIFFEPSLYH CLENCGSV
- Highest antigen sequence identity to orthologs: Mouse – 93%, Rat – 93%
Target Information
Sodium/calcium exchanger proteins are integral membrane proteins primarily found in cardiac cells. In cardiac myocytes, Ca²⁺ concentration alternates between low levels during relaxation and high levels during contraction.
The Na⁺/Ca²⁺ exchanger 1 (NCX1) mediates Ca²⁺ extrusion during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, NCX1.10) arise from alternate splicing. NCX1 mRNA is highly expressed in the heart and at lower levels in the brain. NCX2 is most abundantly expressed in brain tissue, unlike NCX1 which has broader distribution (heart, kidney, lung, smooth and skeletal muscle).
Differences in expression reflect functional diversity among transporter subtypes. Regulatory mechanisms for these exchangers remain incompletely characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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