Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (1A4)
Phospho-JAK2 (Tyr1007, Tyr1008) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 인간 JAK2 단백질에 특이적이며, 고순도 친화 크로마토그래피 정제 및 안정한 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | 1:200–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1A4 |
| Immunogen | A synthesized peptide derived from human Phospho-JAK2 (Y1007 + Y1008) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092686 |
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is known to be mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to modulate gene transcription, including interferon-stimulated genes.
JAK2 is required for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Some studies suggest that Tyk2 and JAK3 could substitute for JAK2 if positioned correctly within the receptor complex. Mutations in JAK2 are associated with Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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