Thermo Fisher Scientific CCBL1 Polyclonal Antibody
인간 CCBL1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관. 신경전달 및 대사 연구용으로 적합.
- 판매단위
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCBL1. Recombinant protein control fragment (Product # RP-93063) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639346 |
Product Specific Information
Immunogen sequence:
MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML NQYTKTFGYP PLTKILASFF GELLGQEIDP LRNVLVTVGG YG
Highest antigen sequence identity to the following orthologs:
- Mouse: 80%
- Rat: 78%
Target Information
Kynurenine aminotransferases (KAT I, KAT II, KAT III) belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic protein involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan.
Kynurenic acid participates in synaptic transmission and has been implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also metabolizes cysteine conjugates of halogenated alkenes and alkanes to form reactive metabolites.
KAT I has three isoforms:
- Isoform 1 – full length protein
- Isoform 2 – lacks amino acids 68–117
- Isoform 3 – lacks amino acids 251–422
Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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