Thermo Fisher Scientific Niemann Pick C1 Polyclonal Antibody, FITC
FITC로 결합된 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 NPC1 단백질을 검출. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 고순도 친화 크로마토그래피 정제 및 안정적 저장 버퍼 구성. 연구용으로만 사용.
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Thermo Fisher Scientific Niemann Pick C1 Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1228–1278 on human Niemann-Pick C1 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene cause a fatal progressive neurodegenerative disorder characterized by abnormal lipid sequestration, including cholesterol and glycosphingolipids.
The NPC1 protein resides in the limiting membrane of endosomes and lysosomes, mediating intracellular cholesterol trafficking via its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments for hydrolysis and release as free cholesterol.
NPC1, along with FTO, MC4R, and PTER, has been identified as a risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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