Thermo Fisher Scientific Phospho-SLP76 (Tyr128) Recombinant Rabbit Monoclonal Antibody (SLP76Y128-3F8)
Recombinant rabbit monoclonal antibody recognizing phospho-SLP76 (Tyr128). High specificity and sensitivity with lot-to-lot consistency. Suitable for flow cytometry in human and mouse samples. Supplied as liquid, unconjugated, with stable storage at -2...
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SLP76Y128-3F8 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896932 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are generated using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal production candidates. These recombinant antibodies offer:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
SLP-76 is a substrate of the ZAP-70 protein tyrosine kinase activated upon T cell receptor (TCR) ligation. The SLP-76 gene is located on human chromosome 5q33 and encodes a 533 amino acid adaptor protein comprising:
- An N-terminal acidic region with a PEST domain and multiple tyrosine phosphorylation sites
- A central proline-rich domain
- A C-terminal SH2 domain
SLP-76 interacts with several proteins constitutively and upon receptor activation, functioning as a scaffold in T cell signaling. Studies using SLP-76 deficient models indicate its essential role in T cell development, activation, and mast cell/platelet function.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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