Thermo Fisher Scientific IL17C Polyclonal Antibody
IL17C 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 시료에 반응합니다. WB, ICC/IF, ELISA에 적합하며, 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 용액 상태로 -20°C 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 19–197 of human IL17C (NP_037410.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.01 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804580 |
Product Specific Information
Immunogen sequence:
HHDPSLRGHP HSHGTPHCYS AEELPLGQAP PHLLARGAKW GQALPVALVS SLEAASHRGR HERPSATTQC PVLRPEEVLE ADTHQRSISP WRYRVDTDED RYPQKLAFAE CLCRGCIDAR TGRETAALNS VRLLQSLLVL RRRPCSRDGS GLPTPGAFAF HTEFIHVPVG CTCVLPRSV
Positive Samples:
HeLa, HepG2, HT-29, Mouse small intestine, Rat lung
Target Information
Cytokine that plays a crucial role in innate immunity of the epithelium, particularly against intestinal bacterial pathogens, acting in an autocrine manner. It stimulates the production of antibacterial peptides and proinflammatory molecules through NF-kappa-B and MAPK pathways. IL17C acts synergistically with IL22 to induce antibacterial peptides such as S100A8, S100A9, REG3A, and REG3G, and with TNF and IL1B to induce DEFB2 from keratinocytes. Depending on the context, IL17C may have both protective and pathogenic roles, maintaining epithelial homeostasis or promoting inflammation. Enhanced IL17C/IL17RE signaling may increase susceptibility to autoimmune diseases.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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