Thermo Fisher Scientific SMAD4 (Pancreatic Adenocarcinoma Marker) Monoclonal Antibody (SMAD4/7901)
인간 SMAD4 단백질을 인식하는 단클론 항체로, 췌장 선암 표지자로 사용됩니다. 파라핀 절편 IHC에 적합하며, 핵 및 세포질 염색 패턴을 보입니다. 단백질 A/G로 정제된 액상 항체로, 4°C에서 보관합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SMAD4/7901 |
| Immunogen | Recombinant fragment (around aa100–300) of human SMAD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human pancreatic adenocarcinoma
- Cellular Location: Nucleus, Cytoplasm
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. Also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic (MAD) homolog 4.
Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) domains responsible for DNA binding and protein interactions.
Upon binding of TGF-beta superfamily ligands (including TGF-beta and BMP) to their receptors, phosphorylation of receptor-regulated Smads (R-Smads: 1, 2, 3, 5, 8) occurs, leading to heterotrimerization with co-Smad (Smad4) and nuclear translocation.
Inhibitory Smads (Smad6, Smad7) modulate this pathway by interacting with activated R-Smads.
Smad4 functions as a tumor suppressor by regulating target genes such as Cyclin D1 (downregulation) and collagen (upregulation), thereby inhibiting cell proliferation. Dephosphorylation controls nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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