Thermo Fisher Scientific IDH1 Monoclonal Antibody (OTI24A2)
IDH1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 파라핀 절편 면역조직화학(IHC)에 적합합니다. 다양한 종에서 반응하며, 고순도 액상 형태로 제공되어 연구용으로 안정적인 신뢰성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI24A2 |
| Immunogen | Synthetic peptide around the R132 region of the human IDH conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723258 |
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent enzymes localized to the mitochondrial matrix, and two NADP(+)-dependent enzymes — one mitochondrial and one cytosolic.
The NADP(+)-dependent cytosolic isozyme encoded by this gene is found in the cytoplasm and peroxisomes, containing a PTS-1 peroxisomal targeting signal.
It plays a role in regenerating NADPH for intraperoxisomal reductions and reactions consuming 2-oxoglutarate, such as alpha-hydroxylation of phytanic acid.
The cytoplasmic enzyme contributes significantly to cytoplasmic NADPH production.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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