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Thermo Fisher Scientific CD40 Monoclonal Antibody (HB14), FITC

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인간 CD40 항원을 인식하는 마우스 단클론 항체로 FITC 형광 표지되어 있습니다. Flow Cytometry에 적합하며 높은 형광 효율과 수용성을 제공합니다. PBS/BSA 완충액에 보관되며 4°C 암소에서 안정적으로 유지됩니다.

카탈로그번호: CD4001
브랜드: Thermo Fisher Scientific
카테고리: Monoclonal Antibodies
판매단위: pk

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마지막 업데이트 2025. 08. 04. 오전 12:46

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Thermo Fisher Scientific CD4001 CD40 Monoclonal Antibody (HB14), FITC 500 ul pk판매 단위 pk ·

재고 확인 필요재고 확인 필요

458,500원VAT 포함 504,350원

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Thermo Fisher Scientific · Thermo Fisher Scientific CD40 Monoclonal Antibody (HB14), FITC

Thermo Fisher Scientific CD40 Monoclonal Antibody (HB14), FITC

Applications

Flow Cytometry (Flow)

Tested Dilution: Assay-Dependent
Publications: View 2 publications

Product Specifications

항목	내용
Species Reactivity	Human
Published Species	Human
Host / Isotype	Mouse / IgG1, kappa
Class	Monoclonal
Type	Antibody
Clone	HB14
Immunogen	Human CD40
Conjugate	FITC
Excitation / Emission Max	498 / 517 nm
Form	Liquid
Purification	Purified
Storage Buffer	PBS with 4 mg/mL BSA
Contains	0.1% sodium azide
Storage Conditions	4°C, store in dark
Shipping Conditions	Ambient (domestic); Wet ice (international)
RRID	AB_2536506

Additional Formats

APC
PE
Custom conjugation available upon request

Product Specific Information

FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

Target Information

The CD40 antigen is a single-chain glycoprotein, part of the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells and is also found on epithelial cells, carcinomas, and lymphoid dendritic cells.

CD40 plays a crucial role in:

T cell-dependent immunoglobulin class switching
Memory B cell development
Germinal center formation

AKNA transcription factor regulates CD40 expression and may influence homotypic cell interactions. TNFR2 adaptor protein mediates CD40 signal transduction. Interaction of CD40 and its ligand is essential for amyloid-beta-induced microglial activation, implicated in early Alzheimer’s disease pathogenesis.

Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include: