Thermo Fisher Scientific CD40 Monoclonal Antibody (HB14), FITC
인간 CD40 항원을 인식하는 마우스 단클론 항체로 FITC 형광 표지되어 있습니다. Flow Cytometry에 적합하며 높은 형광 효율과 수용성을 제공합니다. PBS/BSA 완충액에 보관되며 4°C 암소에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific CD40 Monoclonal Antibody (HB14), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-Dependent
Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HB14 |
| Immunogen | Human CD40 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536506 |
Additional Formats
- APC
- PE
- Custom conjugation available upon request
Product Specific Information
FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
Target Information
The CD40 antigen is a single-chain glycoprotein, part of the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells and is also found on epithelial cells, carcinomas, and lymphoid dendritic cells.
CD40 plays a crucial role in:
- T cell-dependent immunoglobulin class switching
- Memory B cell development
- Germinal center formation
AKNA transcription factor regulates CD40 expression and may influence homotypic cell interactions. TNFR2 adaptor protein mediates CD40 signal transduction. Interaction of CD40 and its ligand is essential for amyloid-beta-induced microglial activation, implicated in early Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include:
- Type 3 Hyper-IgM immunodeficiency
- CD40 ligand deficiency
Notes
Analyte Specific Reagent
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