Thermo Fisher Scientific SMCHD1 Polyclonal Antibody
SMCHD1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피로 정제됨. PBS 기반 완충액, 4°C 또는 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SMCHD1. Recombinant protein control fragment (Product #RP-98295). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647622 |
Product Specific Information
Immunogen sequence:
DNGRGMTSKQ LNNWAVYRLS KFTRQGDFES DHSGYVRPVP VPRSLNSDIS YFGVGGKQAV FFVGQSARMI SKPADSQDVH ELVLSKED
Sequence identity with orthologs:
- Mouse: 97%
- Rat: 98%
Target Information
SMCHD1 is required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with the inactive X chromosome. It participates in a pathway that mediates slow methylation of a subset of CpG islands and requires the de novo methyltransferase DNMT3B. It is also essential for DUX4 silencing in somatic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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