Thermo Fisher Scientific TXK Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LSSYNTIQSV FCCCCCCSVQ KRQMRTQISL STDEELPEKY TQRRRPWLSQ LSNKKQSNTG RVQPSKRKPL PPLPPSEVAE EKIQVKALYD FLP

Antigen sequence identity:
Mouse 72%; Rat 63%

Target Information

TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other receptor types. All members of this family contain SH3 and SH2 domains and, except for Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Four alternatively spliced forms of Tec are expressed broadly in hematopoietic cells and hepatocytes. The Emt gene product associates with CD28 and becomes activated following CD28 ligation. Btk is essential for proper B cell development, and mutations in the Btk gene are associated with X-linked agammaglobulinemia (Bruton’s disease). The Bmx protein shows high homology with Btk and is most highly expressed in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.