Thermo Fisher Scientific SARS-CoV-2 Spike Protein (S1/S2) Recombinant Human Monoclonal Antibody (bcb05)
SARS-CoV-2 Spike Protein(S1/S2)에 특이적인 인간 재조합 단클론 항체. Western blot 및 ELISA에 적합. 고순도(>95%) 및 비결합형 액상 형태. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:3,000
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Human / IgG |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | bcb05 |
| Immunogen | Fully humanized monoclonal antibody paired with human monoclonal antibody corresponding to SARS-CoV-2 Spike Protein (S-ECD) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866564 |
Product Specific Information
- Purity: Greater than 95% as determined by reducing SDS-PAGE
Target Information
SARS-CoV-2(Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold symptoms to severe respiratory distress and death. The Spike(S) protein is critical for viral attachment, fusion, and entry, making it a key target for antibody and vaccine development.
The receptor-binding domain (RBD, S-RBD) in the Spike protein binds strongly to ACE2 receptors in humans and bats, exhibiting higher affinity compared to SARS-CoV RBD.
S1 subunit contains the RBD that specifically binds to ACE2, while S2 mediates membrane fusion.
SARS-CoV-2 Spike protein is 1273 amino acids long, consisting of:
- Signal peptide (1–13)
- S1 subunit (14–685)
- S2 subunit (686–1273)
The S-ECD refers to the extracellular domain of the Spike protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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