Thermo Fisher Scientific Melanophilin Polyclonal Antibody
Melanophilin 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, 합성 펩타이드 면역원으로 제작. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MLPH (Accession Q9BV36), corresponding to amino acid residues K539–H589 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815574 |
Product Specific Information
This antibody detects endogenous levels of total Melanophilin.
Target Information
Slac2-a (synaptotagmin-like protein homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes.
It binds Myosin VA through its C-terminal region and GTP-bound Rab27A through its synaptotagmin-like homology domain (SHD) near the N-terminus.
Transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex.
Mutations in the binding domains of these three protein components may cause albinism and/or severe immune disorders.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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