Thermo Fisher Scientific GRID2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:600

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.

Target Information

GRID2 is a member of the family of ionotropic glutamate receptors, which are the predominant excitatory neurotransmitter receptors in the mammalian brain.
The encoded protein is a multi-pass membrane protein expressed selectively in cerebellar Purkinje cells.
A point mutation in the mouse ortholog (lurcher phenotype) leads to ataxia due to selective apoptosis of Purkinje cells during postnatal development.
Mice homozygous for this mutation die shortly after birth from massive neuronal loss in mid- and hindbrain regions.
This protein also contributes to synapse organization between parallel fibers and Purkinje cells.
Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Mutations in this gene cause cerebellar ataxia in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.