Thermo Fisher Scientific KHDC1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human KHDC1. Recombinant protein control fragment (Product #RP-94834). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KHDC1,uniProtId:Q4VXA5-1,ncbiNodeId:9606,antigenRange:54-114,antigenLength:237,antigenImageFileName:PA5-56041_KHDC1_Q4VXA5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56041_KHDC1_Q4VXA5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642987

Product Specific Information

Immunogen sequence: RERNSRSGKT RCRSKRSEQS MDMGTSALSK KPWWTLPQNF HAPMVFHMEE DQEELIFGHG D

Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 38%.

Target Information

KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability. KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs. KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.