Thermo Fisher Scientific Cardiac Troponin I Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Immunocytochemistry (ICC/IF)

• Tested Concentration: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
PIRRRSSNYR AYATEPHAKK KSKISASRKL QLKTLLLQIA KQELEREAEE RRGEKGRALS TRCQPLELAG LGFAELQ

Target Information

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms part of a complex with troponin C (TnC) and troponin T (TnT).
The TnT subunit binds to tropomyosin, forming a troponin-tropomyosin complex anchored by the binding of TnI to actin within muscle thin filaments.
When calcium binds to specific sites on the regulatory TnC subunit, it induces structural changes that release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.

Measurement of blood TnI and TnT levels is a key diagnostic indicator of heart muscle damage and helps differentiate between angina and myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.