Thermo Fisher Scientific GADD45A Polyclonal Antibody
GADD45A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 토끼 항체. 인간 시료 반응성, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS 및 글리세롤 저장 버퍼 포함. 연구용으로만 사용 가능.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human GADD45A. Recombinant protein control fragment (Product #RP-106462) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662705 |
Product Specific Information
Immunogen sequence:
MTLEEFSAGEQ KTERMDKVGD ALEEVLSKAL SQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 88%
Target Information
GADD45 alpha, beta, and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage.
GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents.
The GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase.
GADD45 forms a complex with p21 and Cdc2, and may serve as a core for interaction with other cell cycle regulators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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