Thermo Fisher Scientific TREX1 Recombinant Rabbit Monoclonal Antibody (ARC0841)
Human TREX1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현되었으며 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific TREX1 Recombinant Rabbit Monoclonal Antibody (ARC0841)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0841 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 150–314 of human TREX1 (Q9NSU2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.13 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849309 |
Product Specific Information
Immunogen sequence:
AFCVDSITAL KALERASSPS EHGPRKSYSL GSIYTRLYGQ SPPDSHTAEG DVLALLSICQ WRPQALLRWV DAHARPFGTI RPMYGVTASA RTKPRPSAVT TTAHLATTRN TSPSLGESRG TKDLPPVKDP GALSREGLLA PLGLLAILTL AVATLYGLSL ATPGE
Target Information
Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It binds single-stranded DNA coated with replication protein A at sites of DNA damage and recruits ATR kinase to these sites. Trex1 is essential for ATR expression. The gene uses two different open reading frames encoding proteins that interact with ATR and localize to intranuclear foci induced by DNA damage. Mutations in this gene are associated with Aicardi-Goutières syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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