Thermo Fisher Scientific TNIP3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TNIP3.

Target Information

The nuclear factor NF-kappa-B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a negative feedback regulator of LPS-induced NF-kappa-B activation.
ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS. It is highly expressed in brain, thymus, lymph node, lung, and fetal liver, with low expression in kidney and bone marrow.
Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals, and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2.
ABIN3 is induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis.
ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappa-B in human macrophages yet is inoperative in mice, representing a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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