Thermo Fisher Scientific TNIP3 Polyclonal Antibody
TNIP3 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 및 생쥐 반응성을 가지며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로 NF-κB 관련 면역 반응 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNIP3 (Accession Q96KP6), corresponding to amino acid residues T77–L127 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852842 |
Product Specific Information
Antibody detects endogenous levels of total TNIP3.
Target Information
The nuclear factor NF-kappa-B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a negative feedback regulator of LPS-induced NF-kappa-B activation.
ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS. It is highly expressed in brain, thymus, lymph node, lung, and fetal liver, with low expression in kidney and bone marrow.
Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals, and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2.
ABIN3 is induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis.
ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappa-B in human macrophages yet is inoperative in mice, representing a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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