Thermo Fisher Scientific KLC2 Monoclonal Antibody (OTI10H10)
KLC2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P) 검증 완료. 인간 시료 반응성, 비접합형 액상 제품. 고순도 친화 크로마토그래피 정제, 안정적 PBS/BSA/glycerol 버퍼 구성. 연구용 단백질 분석에 적합.
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Thermo Fisher Scientific KLC2 Monoclonal Antibody (OTI10H10)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 335–622 of KLC2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724571 |
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:
- Ubiquitin C-terminal hydrolases
- Ubiquitin-specific processing proteases (USPs)
- OTU-domain ubiquitin-aldehyde-binding proteins
- Jab1/Pad1/MPN-domain-containing metallo-enzymes
Among these, USPs are the most widespread and conserved across evolution. They release ubiquitin from conjugated proteins and contain conserved catalytic domains with Cys and His boxes, while their N- and C-terminal extensions contribute to substrate recognition and protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MA5-27479_KLC2_Q9H0B6-1_House_mouse.svg)
(이미지: MA5-27479_KLC2_Q9H0B6-1_House_mouse_PDP.jpeg)
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