Thermo Fisher Scientific Human PPARD, Ligand Binding Domain, GST Tag Recombinant Protein

Applications

• Ligand Binding Assay (LBA)

Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Peroxisome Proliferator Activated Receptor delta, Ligand Binding Domain (PPARδ-LBD) is a 59.90 kDa recombinant human protein (amino acids 165–441) expressed as a GST-tagged fusion protein in E. coli cells.
PPARδ-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.

Protein Form: Recombinant, Ligand Binding Domain

Target Information

The PPARD gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family, which are nuclear hormone receptors that regulate peroxisome proliferation and various metabolic processes.
PPARs are involved in biological pathways related to diabetes, obesity, atherosclerosis, and cancer.
This protein acts as a potent inhibitor of ligand-induced transcription activity of PPARα and PPARγ and may function as an integrator of transcription repression and nuclear receptor signaling.
Elevated expression of this gene is observed in colorectal cancer cells and can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein associated with the APC/β-catenin pathway.
Knockout studies in mice suggest roles in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.