Thermo Fisher Scientific SEMA3F Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
TPPYQELAQL LAQPEVGLIH QYCQGYWRHV PPSPREAPGA PRSPEPQDQK KPRNRRHHPP DT

Highest antigen sequence identity to the following orthologs:

• Mouse: 94%
• Rat: 94%

Target Information

The semaphorins are a family of proteins involved in signaling. All family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]).
Sequence comparisons have grouped the secreted semaphorins into three general classes, all of which also have an immunoglobulin domain. The semaphorin III family, including human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus.
Chicken collapsin contributes to axon pathfinding during development by inhibiting growth cone extension (Luo et al., 1993 [PubMed 8402908]) through interaction with CRMP62 (Goshima et al., 1995 [PubMed 7637782]), a homolog of the UNC33 gene product (MIM 601168).
SEMA3F is a secreted member of the semaphorin III family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.