Thermo Fisher Scientific PDX1 Polyclonal Antibody
PDX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot 및 ELISA에 적합합니다. 인간 및 생쥐 반응성을 가지며 액상 형태로 제공됩니다. 인슐린 유전자 발현 조절 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human PDX1 (NP_0002001) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804351 |
Product Specific Information
- Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF
- Positive Samples: DU145, HepG2, Mouse pancreas, Mouse liver
- Cellular Location: Cytoplasm, Nucleus, Cytosol
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in early pancreatic development and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are associated with pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM) and maturity onset diabetes of the young type 4 (MODY4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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