Thermo Fisher Scientific TOPORS Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse Topors (NP_5988582) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOPORS,uniProtId:Q9NS56-1,ncbiNodeId:9606,antigenRange:176-192,antigenLength:1045,antigenImageFileName:PA5-116849_TOPORS_Q9NS56-1_Rabbit.svg,antigenImageFileNamePDP:PA5-116849_TOPORS_Q9NS56-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:TOPORS,uniProtId:Q80Z37-1,ncbiNodeId:10090,antigenRange:100-200,antigenLength:1033,antigenImageFileName:PA5-116849_TOPORS_Q80Z37-1_Rabbit.svg,antigenImageFileNamePDP:PA5-116849_TOPORS_Q80Z37-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901480

Product Specific Information

Positive Samples: Mouse liver, Mouse lung, Mouse kideny, Rat kidney

Immunogen sequence: PDSKCPICLD RFDNVSYLDR CLHKFCFRCV QEWSKNKAEC PLCKQPFDSI FHSVRAEDDF KEYVLRPSYN GSFTNPEVRR FRYRTTMTRE RSASLYSPSS T

Target Information

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.