Thermo Fisher Scientific LGR7 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 10–13 µg/mL

Product Specifications

Product Specific Information

PA1-20464 detects G Protein-Coupled Receptor LGR7 in human samples.

Target Information

LGR7 is a low-density lipoprotein receptor of 757 amino acids belonging to the G-protein coupled receptor 1 family with rhodopsin-like receptor activity.
It has seven transmembrane regions, a cysteine-rich motif, 10 LRR domains, and 5 N-glycosylation sites in the N terminus.
Research reports show that it acts as a receptor for relaxins (RLN1 and RLN2), stimulating adenylate cyclase activation, substrate adhesion, and chemo-migratory capacity of mononuclear leukocytes.
LGR7 is critical for mediating these biological responses via RNA interference lentiviral short hairpin constructs.
It is widely expressed in 86% of 15 primary EC tissue samples including brain, kidney, testis, and endometrium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.