Thermo Fisher Scientific RFWD3 Polyclonal Antibody
Human RFWD3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. DNA 손상 복구 관련 E3 유비퀴틴 리가아제 연구용으로 사용되며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다.
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Thermo Fisher Scientific RFWD3 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human RFWD3 (UniProt ID: Q6PCD5-1, Antigen Range: 133–152) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635574 |
Product Specific Information
This antibody detects endogenous levels of total RFWD3 protein.
Target Information
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Mediates ubiquitination of the RPA complex (RPA1, RPA2, RPA3) and RAD51 at stalled replication forks, promoting homologous recombination. Also mediates ubiquitination of p53/TP53, acting as a positive regulator of p53 stability and the G1/S DNA damage checkpoint. In response to ionizing radiation, interacts with MDM2 and enhances p53 ubiquitination, possibly restricting MDM2 from extending polyubiquitin chains on p53.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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