Thermo Fisher Scientific CDKN2A (Isoform 3) Polyclonal Antibody
CDKN2A (Isoform 3) 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. 인간 시료에 반응하며 Western blot에 적합. 고순도 정제 및 안정적 액상 형태로 제공. 암 억제 관련 연구용으로 최적화된 제품.
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Applications
Tested Application
- Western Blot (WB)
Tested Dilution
- 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-ILRKKGRLPGEFSE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932861 |
Product Specific Information
- This antibody is expected to recognize the pancreas isoform (NP_478104.1) only.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which function as inhibitors of CDK4 kinase. Another transcript encodes an alternate open reading frame (ARF) product that stabilizes the tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product share a role in cell cycle G1 control. This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.
[provided by RefSeq, Sep 2012]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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