Thermo Fisher Scientific CDKN2A (Isoform 3) Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB)

Tested Dilution

• 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize the pancreas isoform (NP_478104.1) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which function as inhibitors of CDK4 kinase. Another transcript encodes an alternate open reading frame (ARF) product that stabilizes the tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product share a role in cell cycle G1 control. This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.
[provided by RefSeq, Sep 2012]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.