Thermo Fisher Scientific DBNL Monoclonal Antibody (OTI6C9), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.
The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity and may act as a DNA unwinding enzyme.
The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex.
This gene is mapped to a region on chromosome 8, head-to-head next to PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.
Alternatively spliced transcript variants encoding the same protein have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.