Thermo Fisher Scientific FOXL2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Goat: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Target Information

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical evolutionary role, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and follicle development or maintenance.
Immunohistochemical data show that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells, without major posttranslational modifications.
FOXL2 is associated with blepharophimosis/ptosis/epicanthus inversus syndrome (BPES). Type I BPES includes eyelid abnormalities with ovarian failure, while Type II BPES involves only eyelid defects. Studies indicate FOXL2 expression in developing mouse eyelid mesenchyme and adult ovarian follicles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.