Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 사용 가능. 액상 형태로 1 mg/mL 농도, 4°C 보관. 연구용으로 Toll/IL-1 신호 경로 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 662 and 712 of human Interleukin-1 Receptor-Associated Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways.
IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.
Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and degradation.
IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7), inducing activation and nuclear translocation.
This results in transcriptional activation of type I IFN genes, driving the cell into an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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