Thermo Fisher Scientific SARM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• 1:200

Product Specifications

Target Information

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death involving degeneration of an axon distal to the injury site.
Wallerian degeneration is triggered by NAD(+) depletion: upon injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR), and nicotinamide, promoting cytoskeletal degradation and axon destruction.
Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response by inhibiting TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, NF-kappa-B, and IRF3, and phosphorylation of MAPK14/p38.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: BS-9001R_SARM_Q6SZW1-1_Rabbit.svg, BS-9001R_SARM_Q6SZW1-1_Rabbit_PDP.jpeg)