Thermo Fisher Scientific SARM1 Polyclonal Antibody
SARM1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 생쥐, 랫트 반응성. Western blot 및 IHC(P)용으로 검증됨. KLH 결합 합성 펩타이드(aa 340–380)로 면역화. 액상 형태, Protein A 정제, -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SARM1, amino acids 340–380 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death involving degeneration of an axon distal to the injury site.
Wallerian degeneration is triggered by NAD(+) depletion: upon injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR), and nicotinamide, promoting cytoskeletal degradation and axon destruction.
Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response by inhibiting TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, NF-kappa-B, and IRF3, and phosphorylation of MAPK14/p38.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: BS-9001R_SARM_Q6SZW1-1_Rabbit.svg, BS-9001R_SARM_Q6SZW1-1_Rabbit_PDP.jpeg)
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