Thermo Fisher Scientific MARCKS-like1 Polyclonal Antibody
MARCKS-like1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, IP 등 다양한 응용에 적합하며, 4°C에서 보관. 인간 및 마우스에서 반응 예측. FFPE 조직에는 citrate buffer pH 6.0 처리 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 5–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 145 and 195 of human myristoylated alanine-rich C kinase substrate-like 1 (MARCKSL1, UniProt ID: P49006-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
MARCKS (Myristoylated alanine-rich protein kinase C substrate), also designated 80K or 80K-L, is a 332 amino acid protein localized to the plasma membrane and serves as a major substrate for protein kinase C (PKC).
MARCKSL1 (MARCKS-like protein 1), also known as MacMARCKS, MLP, MRP, or F52, is a 195 amino acid protein and a major PKC substrate. It is expressed in various tissues, with the highest levels in testis and uterus. MARCKSL1 is involved in membrane-cytoskeletal signaling events such as secretion, migration, phagocytosis, and cell adhesion.
Additionally, MARCKSL1 regulates Integrin activation and Integrin-dependent signal transduction pathways, particularly those involved in macrophage spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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