Thermo Fisher Scientific RANKL Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This antibody is expected to recognise both reported isoforms (NP_003692.1 and NP_143026.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
This protein acts as a dendritic cell survival factor and participates in the regulation of T cell-dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, lack of osteoclasts, defects in T/B lymphocyte differentiation, and failure to form mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.