Thermo Fisher Scientific S1P1 Polyclonal Antibody
Thermo Fisher Scientific의 S1P1 Polyclonal Antibody는 Zebrafish 시료에 반응하며 Rabbit IgG 호스트 기반의 폴리클로날 항체입니다. Western blot에 최적화되어 있으며 KLH 접합 합성 펩타이드로 면역원 제작되었습니다. 단백질 A 및 항원 친화 크로마토그래피로 정제되어 연구용으로 사용됩니다.
- 카탈로그번호
- PA572648
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 311-335 amino acids from the C-terminal region of DANRE s1pr1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718502 |
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins.
S1P1 signaling leads to activation of RAC1, SRC, PTK2/FAK1, and MAP kinases.
It plays an important role in cell migration via reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase sphingosine kinase SPHK1 activity.
S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, embryonic heart development, and cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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