Thermo Fisher Scientific MS4A1 Monoclonal Antibody (5C11)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
GIVENEWKRT CSRPKSNIVL LSAEEKKEQT IEIKEEVVGL TETSSQPKNE EDIEIIPIQE EEEEETETNF PEPPQDQESS PIENDSSP

Target Information

CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation.
It is expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells.
CD20 regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
It is associated with lipid rafts, with the intensity of this association influenced by extracellular triggering or BCR aggregation.
Following receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, while CD20 remains at the surface.
CD20 is a useful target for antibody-mediated therapeutic depletion of B cells, as it is highly expressed on B-cell malignancies and remains membrane-bound after treatment.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.