Thermo Fisher Scientific ZBTB4 Polyclonal Antibody
인간 ZBTB4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. ZBTB4의 메틸화 DNA 결합 및 전사 억제 연구에 적합.
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- PA564181
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZBTB4. Recombinant protein control fragment (Product # RP-103705) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649772 |
Product Specific Information
Immunogen sequence:
TPTPVIAYSK GSAGTRPGDV KEEAPQEMQV SSSSGEAGGG STAAEEASET ASLQDPIISG GEEPPVVASG GSYVYPPV
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 86%
Target Information
The ZBTB family of proteins comprises diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger protein that binds methylated CpGs, ZBTB4 can bind methylated DNA and repress transcription. ZBTB4 associates with the Sin3/histone deacetylase co-repressor and represses expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal growth conditions; this degradation increases with DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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