Thermo Fisher Scientific eIF4G3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human eIF4G3. Recombinant protein control fragment (Product #RP-94019). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:eIF4G3,uniProtId:O43432-1,ncbiNodeId:9606,antigenRange:155-258,antigenLength:1585,antigenImageFileName:PA5-55212_eIF4G3_O43432-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55212_eIF4G3_O43432-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640975

Product Specific Information

Immunogen sequence: TEEIMSGGGS RNPTPPIGRP TSTPTPPQQL PSQVPEHSPV VYGTVESAHL AASTPVTAAS DQKQEEKPKP DPVLKSPSPV LRLVLSGEKK EQEGQTSETT AIVS

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.

Target Information

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.