Thermo Fisher Scientific FPGS Recombinant Rabbit Monoclonal Antibody (7E2H1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7E2H1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FPGS,uniProtId:Q05932-1,ncbiNodeId:9606,antigenRange:450-587,antigenLength:587,antigenImageFileName:MA5-55448_FPGS_Q05932-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55448_FPGS_Q05932-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: NADQQNFTVT LDQVLLRCLE HQQHWNHLDE EQASPDLWSA PSPEPGGSAS LLLAPHPPHT CSASSLVFSC ISHALQWISQ GRDPIFQPPS PPKGLLTHPV AHSGASILRE AAAIHVLVTG SLHLVGGVLK LLEPALSQ

Target Information

Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis. Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.