Thermo Fisher Scientific FPGS Recombinant Rabbit Monoclonal Antibody (7E2H1)
Recombinant Rabbit Monoclonal Antibody targeting human FPGS (clone 7E2H1). Validated for WB and ELISA. Expressed in HEK293 cells, purified by Protein A. Supplied as liquid form, unconjugated, with high specificity for folylpoly-gamma-glutamate synthetase.
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- MA555448
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:500
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E2H1 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 450–587 of human FPGS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
NADQQNFTVT LDQVLLRCLE HQQHWNHLDE EQASPDLWSA PSPEPGGSAS LLLAPHPPHT CSASSLVFSC ISHALQWISQ GRDPIFQPPS PPKGLLTHPV AHSGASILRE AAAIHVLVTG SLHLVGGVLK LLEPALSQ
Target Information
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.
FPGS plays a crucial role in folate homeostasis in mammals by:
- Preventing efflux of folate cofactors from cells via polyglutamation
- Enhancing binding of folate cofactors to enzymes involved in folate interconversion and biosynthesis
- Facilitating accumulation of folates in mitochondria for glycine synthesis
FPGS is widely expressed in human tumors and is associated with cell proliferation or lack of differentiation. Its integrative function increases the efficiency of folate antimetabolites used in cytotoxic therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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