Thermo Fisher Scientific KIDINS220 Polyclonal Antibody
KIDINS220 단백질을 검출하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫드 반응성. 고순도 Affinity 정제 및 PBS/glycerol 버퍼로 안정 보관. 신경세포 생존 및 분화 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIDINS220 (Accession Q9ULH0), corresponding to amino acid residues R381–T431 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815682 |
Product Specific Information
Antibody detects endogenous levels of total KIDINS220.
Target Information
The KIDINS220 gene encodes a transmembrane protein predominantly expressed in the nervous system, where it regulates neuronal cell survival, differentiation of axons and dendrites, and synaptic plasticity.
This protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, functioning as a scaffold that mediates crosstalk between the neurotrophin pathway and other intracellular signaling pathways.
Aberrant expression is linked to neuropsychiatric and neurodegenerative disorders, including Alzheimer’s disease.
Mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity.
Alternative splicing results in multiple transcript variants.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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