Thermo Fisher Scientific GLYR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GLYR1. Recombinant protein control fragment (Product #RP-103018). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GLYR1,uniProtId:Q49A26-1,ncbiNodeId:9606,antigenRange:26-106,antigenLength:553,antigenImageFileName:PA5-61690_GLYR1_Q49A26-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61690_GLYR1_Q49A26-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642063

Product Specific Information

Immunogen sequence: IVNPPKDLKK PRGKKCFFVK FFGTEDHAWI KVEQLKPYHA HKEEMIKINK GKRFQQAVDA VEEFLRRAKG KDQTSSHNSS D

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Target Information

GLYR1 may have oxidoreductase activity. It regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. It indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. It is recruited on chromatin, recognizes and binds trimethylated Lys-36 of histone H3 (H3K36me3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.