Thermo Fisher Scientific TERT Polyclonal Antibody
TERT 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합. 인간 시료에 반응하며, 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- OST00052W-100UL
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 610–660 of human Telomerase reverse transcriptase (TERT) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TERT.
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of:
- A protein component with reverse transcriptase activity (encoded by the TERT gene)
- An RNA component serving as a template for telomere repeat synthesis.
Telomerase expression is typically repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence.
Deregulation of telomerase expression may contribute to oncogenesis.
In mice, telomerase also participates in chromosomal repair, as de novo synthesis of telomere repeats may occur at double-stranded breaks.
Alternative splicing of the TERT gene produces multiple isoforms, some of which are incompletely characterized, and is considered a regulatory mechanism for telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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