Thermo Fisher Scientific CCM2 Monoclonal Antibody (OTI2E4)
CCM2 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI2E4). Western blot, IHC, ICC/IF에 사용 가능. 인간 시료에 반응하며, 액상 형태로 제공. 고순도 친화 크로마토그래피 정제 및 안정적 PBS 버퍼에 보관.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E4 |
| Immunogen | Full length human recombinant protein of CCM2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724051 |
Target Information
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade.
The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation.
It is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Mutations in this gene result in cerebral cavernous malformations.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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