Thermo Fisher Scientific Fe65 Recombinant Rabbit Monoclonal Antibody (23GB3665)
Fe65 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. 인간 시료 반응성이 있으며, HEK293F 시스템에서 발현되었습니다. 알츠하이머병 관련 단백질 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3665 |
| Immunogen | A synthetic peptide of human FE65 (650–710AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The protein encoded by this gene is a member of the Fe65 protein family and functions as an adaptor protein localized in the nucleus. It interacts with Alzheimer’s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1, and low-density lipoprotein receptor-related protein. APP acts as a cytosolic anchoring site preventing the nuclear translocation of this protein. The encoded protein may play an important role in Alzheimer’s disease pathogenesis, regulate transcription, and block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described, though some full-length sequences are unknown.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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