Thermo Fisher Scientific Factor VII Recombinant Rabbit Monoclonal Antibody (003)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse Coagulation Factor VII.

Target Information

Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. It circulates in the blood as a zymogen and is converted to its active form by minor proteolysis via factor IXa, factor Xa, factor XIIa, or thrombin. Upon activation, a heavy chain with a catalytic domain and a light chain with two EGF-like domains are formed, linked by a disulfide bond.

In the presence of factor III and calcium ions, activated factor VII triggers the coagulation cascade by converting factor IX to IXa and/or factor X to Xa. Defects in F7 production can lead to coagulopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.