Thermo Fisher Scientific RNASE3 Polyclonal Antibody
RNASE3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 ICC/IF에 적합하며, 인간 시료에 반응. 단백질 A 및 항원 친화 크로마토그래피로 정제된 고순도 항체로, 연구용으로 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 124–151 of human RNASE3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634052 |
Target Information
ECP (Eosinophil Cationic Protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160-amino-acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family. ECP localizes to the granule matrix of eosinophils and participates in immune responses. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils, exhibiting anti-parasitic, antibacterial, and ribonucleolytic activities. Elevated ECP levels are associated with eosinophilic inflammation, asthma, and allergic diseases. It is also implicated in neurotoxic effects such as the Gordon phenomenon, characterized by ataxia, muscular rigidity, paralysis, and tremor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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