Thermo Fisher Scientific IL-27 p28 Recombinant Rabbit Monoclonal Antibody (001)

Thermo Fisher Scientific IL-27 p28 Recombinant Rabbit Monoclonal Antibody (Clone 001)

Applications

• ELISA

Tested Dilution

• 1:5,000–1:10,000

Publications

• [References not available]

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal production clones.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody specifically recognizes Human IL-27.

Target Information

IL-27 is a member of the IL-12 family, composed of the p40-related EBI3 protein and the IL-12p35-related p28 (IL-30) protein.
Produced by activated APCs and mature dendritic cells, IL-27 acts on NK cells and naïve CD4+ T cells. It also affects mast cells and monocytes via WSX-1/TCCR and gp130 receptors.
Binding to WSX-1/gp130 activates JAK1, STAT1, and STAT3 pathways. WSX-1-deficient mice show impaired Th1 responses and increased infection susceptibility, indicating IL-27’s role in initiating Th1 differentiation.
IL-27 induces T-bet and suppresses GATA-3, promoting Th1 differentiation and maintaining IL-12Rβ2 expression.
Recent studies show IL-27’s antitumor activity through CTL enhancement, tumor growth inhibition, and regression of neuroblastoma tumors.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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